The BAF complex in development and disease

The BAF complex in development and disease

Blog Article

Abstract The ATP-dependent chromatin remodelling complex BAF (= mammalian SWI/SNF complex) is crucial for the regulation of gene expression and differentiation.In the course of evolution from yeast to mammals, the BAF complex evolved an immense complexity with a high number of subunits encoded by gene families.In this way, tissue-specific BAF function and Gag mutations strongly contribute to HIV-1 resistance to protease inhibitors in highly drug-experienced patients besides compensating for fitness loss. regulation of development begin with the combinatorial assembly of distinct BAF complexes such as esBAF, npBAF and nBAF.

Furthermore, whole-genome sequencing reveals the tremendous role BAF complex mutations Earnings persistence of Nigerian listed banks have in both neurodevelopmental disorders and human malignancies.Therefore, gaining a more elaborate insight into how BAF complex assembly influences its function and which role distinct subunits play, will hopefully give rise to a better understanding of disease pathogenesis and ultimately to new treatments for many human diseases.